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In women with PCOS the menstrual cycle begins with irregular production and release of hormones. PCOS is Polycystic Ovarian Syndrome. It’s also called as PCOD which stands for Polycystic Ovarian Disease.
The hypothalamus releases GnRH in a higher than normal pulsatile frequency in women with PCOS. This allows for increased LH and decreased FSH, this in turn leads to excessive production of the androgens androstenedione and testosterone. This causes the follicle to only mature some, but not enough to achieve full maturity. This also allows for continued increase of estrogen, primarily estrone. The higher levels of androgens and estrogen create a chronic state of low to very low progesterone. Classic polycystic ovaries are a result of chronic anovulation. Endocrine function is imbalanced from the very beginning of the cycle causing mild to severe hormonal imbalance, depending on the individual.
Are you having these Symptoms Of PCOS
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The Food and Drug Administration is warning that that the antibiotic azithromycin can cause dangerous changes in heart rhythm in patients already taking medications for heart arrhythmia. (Kari Rene Hall / Los Angeles Times)
The U.S. Food and Drug Administration on Tuesday warned that the widely prescribed antibiotic azithromycin — marketed as Zithromax and Zmax — may cause potentially fatal changes in the heart rhythm of people who are taking medications to treat existing heart arrhythmia or who have a slower-than normal heart beat or magnesium or potassium deficiencies.
Patients with a prolonged QT interval, a heart rhythm irregularity that is a risk factor for ventricular arrhythmias, also should avoid use of the antibiotic, the FDA warned.
Azithromycin, one of the most commonly prescribed antibiotics, is used to treat bacterial infections such as ear infections in children, urinary infections, bronchitis, pneumonia and chlamydia, a sexually transmitted disease.
The FDA’s finding follows a warning about the potential for dangerous heart arrhythmias in certain patients taking the antibiotic levofloxacin (marketed as Levaquin). Levofloxacin and azithromycin were found to pose the same risk of death in heart patients. Two other antibiotics — amoxycillin and ciprofloxacin — did not increase those patients’ risks, the FDA said.
Reff.LATimes
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